WG1
Heart Failure
Lead: UMF Carol Davila
Partners: CO, P1, P2, P3, P5
MAIN OBJECTIVE
Understanding molecular and pathophysiological mechanisms of HFpEF, HFrEF and HFmrEF, developing predictive models based on multimodal imaging, biomarkers and AI, and assessing cardiotoxicity related to oncologic therapies.
Research Work Packages
WP1.1Predictive models in HFpEF: multimodal imaging, CPET, novel biomarkersPlanned
Prospective and retrospective clinical studies, animal and in vitro models, multi-omics, multimodal imaging, applied machine learning and structured data collection per the project DMP.
WP1.2HFpEF animal models: metabolic, hemodynamic, amyloidPlanned
Prospective and retrospective clinical studies, animal and in vitro models, multi-omics, multimodal imaging, applied machine learning and structured data collection per the project DMP.
WP1.3Predictive models in HFrEF and HFmrEF: molecular & genetic profilingPlanned
Prospective and retrospective clinical studies, animal and in vitro models, multi-omics, multimodal imaging, applied machine learning and structured data collection per the project DMP.
WP1.4In vitro & in vivo models for chemotherapy cardiotoxicityPlanned
Prospective and retrospective clinical studies, animal and in vitro models, multi-omics, multimodal imaging, applied machine learning and structured data collection per the project DMP.
WP1.5SCD risk: multiparametric AI for ICD selectionPlanned
Prospective and retrospective clinical studies, animal and in vitro models, multi-omics, multimodal imaging, applied machine learning and structured data collection per the project DMP.
WP1.6Thoracic radiotherapy cardiotoxicity prediction + telerehabilitationPlanned
Prospective and retrospective clinical studies, animal and in vitro models, multi-omics, multimodal imaging, applied machine learning and structured data collection per the project DMP.
Deliverables & targets
| Deliverable | Type | Month | Status |
|---|---|---|---|
| — | — | M12 | Planned |
| — | — | M24 | Planned |
| — | — | M36 | Planned |
| — | — | M48 | Planned |
| — | — | M60 | Planned |
Related publications
Publications will appear as they are registered.